Synthesis, Evaluation and in silico studies of 1,8-Naphthyridine derivatives against antimicrobial activity

Sakshi Sachdeva, Sonam Bhatia, Amit Mittal, Manish Sinha
2015 Journal of Applied Pharmaceutical Science  
In present studies a series of novel 1,8-Naphthyridine derivatives (3a-3f) have been synthesized using nalidixic acid as a starting material. The structures of the compounds were supported by FT-IR, 1 H NMR and Mass spectral data. All the synthesized compounds have been evaluated in vitro for their antibacterial activities against several strains of microbes using agar dilution method. The synthesized compounds had moderate to good antibacterial activity. Molecular docking studies reveal that
more » ... udies reveal that 1,8-Naphthyridine scaffold shared structural complimentary with DNA Gyrase B. Further, TOPKAT analysis on Ames mutagenicity model had shown that this class of compounds have least probability of showing toxicity on experimental animal models.
doi:10.7324/japs.2015.50709 fatcat:4qvkosgejbeo7hlfqk4dolhg5e