Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Alina Minarowska, Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko
2012 Folia Histochemica et Cytobiologica  
Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A
doi:10.5603/fhc.2012.0003 fatcat:avnldcypcvaudljxexvytc5yce