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The genetic variant of COX-2 acts as a potential risk factor of colorectal cancer: evidence from a meta-analysis based on 13461 individuals
2015
Integrative Molecular Medicine
Cyclooxygenase-2 (COX-2) plays a crucial role in colorectal carcinogenesis. Accumulating studies investigating the association between COX-2 genetic variants (-765G>C, -1195G>A, and 8473T>C) and colorectal cancer (CRC) susceptibility generated conflicting results. To explore the potential correlation, we conducted a meta-analysis based on eligible case-control epidemiological studies. Databases of Medline, Embase and CNKI were screened for eligible papers focusing on the relationship between
doi:10.15761/imm.1000184
fatcat:5cijotvapjhwhlc75rixlenk5y