The knowledge about indigenous therapeutics was deposited in the ayurvedic classics like Charaka Samhita, Sushruta Samhita, Ashtanga hrudaya etc. These works of ancient period mainly incorporated herbal formulation and a few herbo-mineral compounds. During medieval period the works like Gadanigraha, Chakradatta and Saranagadhara Samhita included certain herbo-mineral and mineral preparations (containing mercury and certain heavy metal like Gold, Lead etc.). Among the herbo-mineral preparations

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... handraprabhaVati was formulated with broad spectrum activity. It is a safe formulation containing Loha (Iron)and shilajita (Bitumen) without any heavy metals.Certain researches had been carried out related to its hypoglycaemic, hypotensive and bacteriostatic activities.Pharmaco-therapeutic profile clearly indicate that Chandraprabha Vati is useful in 31 disease conditions like Prameha (Urinary disease including diabetes), Ashmari (Urolithiasis), Katishoola (lumbago), Shoola (Pain in abdomen), Kamala (Jaundice), Pleeharoga (Splenomegaly), Arsha (Piles), Bhagandhara (Fistula in ano), shukradosha (Defective spermatogenesis), Artavaruja (Dysmenorrhea)etc. The details are furnished in this paper.