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The knowledge about indigenous therapeutics was deposited in the ayurvedic classics like Charaka Samhita, Sushruta Samhita, Ashtanga hrudaya etc. These works of ancient period mainly incorporated herbal formulation and a few herbo-mineral compounds. During medieval period the works like Gadanigraha, Chakradatta and Saranagadhara Samhita included certain herbo-mineral and mineral preparations (containing mercury and certain heavy metal like Gold, Lead etc.). Among the herbo-mineral preparationsfatcat:evwuab4uizg5rmbmbo637vgx2m