LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES where the hypertensive response to isometric hand grip exercise is discussed, it would have been nice to see a reference to Lind and his colleagues who first demonstrated the response. It was good to see a chapter about autonomic failure in the elderly. The extensive studies of the incidence of orthostatic hypotension, thermoregulatory impairment and the relationship of Parkinsons and cerebrovascular diseases to autonomic dysfunction in older

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... are very well discussed. Almost every form of autonomic dysfunction from multiple system atrophy, familial dysautonomia, amyloid disruption of autonomic fibres, to problems of autonomic outflow to the eyes and many others are well discussed, with descriptions of clinical presentations, pathology, neurochemistry and investigative procedures. Associated problems such as ion and fluid homeostasis alterations receive attention. The book ends with an exciting chapter on experimental studies of immune autonomic neuropathies. Throughout the book, present knowledge is supplemented with exciting experimental work in progress, and quantitative measuring techniques are presented to aid our studies of patients with autonomic nervous system disease, and attention is given to the difficult problems of management of these patients. The reference lists are extensive and the book is well indexed. It is a "state of the art" book, which, by its many stimulating discussions, will promote research work which will produce a need for a new edition in a few years. Though fairly expensive, this book is mandatory for the bookshelves of any physician, neurosurgeon or physiologist with a major interest in the autonomic nervous system.