PHARMACOLOGICAL EVALUATIO OF Enhydra fluctuans AERIAL PARTS FOR CETRAL ERVOUS SYSTEM DEPRESSAT ACTIVITY

Sudipto Kumar, Roy, Upal Kanti Mazumder, Aminul Islam, Sudipto Kumar, Roy
unpublished
In the present study, some neuropharmacological effects of three fractions (Benzene, Chloroform and Ethyl Acetate) of methanolic extract of Enhydra fluctuans were studied in mice using various models. The effect of the three fractions (100mg/kg,b.w, i.p) of Enhydra fluctuans on central and peripheral nervous system were studied by using spontaneous motor activity, sedative activity, anticonvulsant property, anti-stress activity by tail suspension test (TST) and forced swimming test (FST).
more » ... inary phytochemical evaluation of extract was also carried out. The methanolic extract of Enhydra fluctuans was found to be safe upto a dose of 2000 mg/kg body weight, i. p. on Swiss Albino mice. Only benzene, chloroform and ethyl acetate fractions produced CNS depressant activity. Preliminary phytochemical analysis of the extract revealed the presence of alkaloids, saponins, flavonoids, triterpenoids/steroids, tannins, carbohydrates and glycosides. The results of the present study indicated significant spontaneous motility depressant, sedative, anticonvulsant and anti-stress activity of the different fractions in the tested animal models. Therefore, from the present study it may be concluded that different fractions of Enhydra fluctuans aerial parts possess central nervous system depressant activity.
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