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Tumor and marrow damage occurring from methotrexate, monofluoromethotrexate, difluoromethotrexate, and dichloromethotrexate
The effects of methotrexate, 3',5'-dichloromethotrexate (DCM), and two new antifolic acid compounds, monofluoromethotrexate (MFM) and difluoromethotrexate (DFM), on the C3H mouse marrow count and a transplanted tumor, the 6C3HED lymphosarcoma, were studied. The data were presented in the following forms: plots of the regression lines of marrow counts and tumor weight responses against dose of compound used; slopes of the regression lines; relative potencies of the bone marrow destruction; andpmid:13781792 fatcat:i6hbc2hjhvfqzo3lie55z6n7c4