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Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
[article]
2022
bioRxiv
pre-print
ABSTRACTThere is a growing interest in continuous processing of the biopharmaceutical industry. However, the technology transfer from traditional batch-based processes is considered a challenge as protocol and tools still remain to be established for their usage at the manufacturing scale. Here, we present a model-based approach to design optimized perfusion cultures of CHO cells using only the knowledge captured during small-scale fed-batch experiments. The novelty of the proposed model lies
doi:10.1101/2022.05.19.492635
fatcat:hecsffoth5h65i4pewphirl26e