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Electro-acupuncture alleviates METH withdrawal-induced spatial memory deficits by restoring astrocyte-derived glutamate uptake in dCA1
AbstractMethamphetamine (METH) is frequently abused drug and produces cognitive deficits. METH could induce hyper-glutamatergic state in the brain, which could partially explain METH-related cognitive deficits, but the synaptic etiology remains unclear. Here, we investigated the role of dCA1 tripartite synapses and the potential therapeutic effects of electro-acupuncture (EA) in the METH withdrawal-induced spatial memory deficits. METH withdrawal weakened astrocytic capacity of Glu uptake, butdoi:10.1101/2020.05.20.106153 fatcat:gxnyi7tlgrclrfmdd3zn5pkueq