For the evaluation of the effect of intraarterial chemotherapy with CDDP (cis-diaminedichloroplatinum) in the treatment of osteogenic sarcoma. we compared radiographic findings of magnetic resonance imaging (MRI) and intraartcrial digital subtraction angiography (IA DSA) with the degree oftumor necrosis in pathologic specimens. The d ecrease in neovascularity and tumor stain in IA DSA showed good correlation with tumor response (necrosis) to IA chemoth erapy ' MRI was useful in the localization

more »

... of intra -and extramedulla ry tumor. and detection of skip metastases' but signal intensity changes showed poor correlation with tumor response to chemotherapy. In gadolinium di ethyltriamine pentaacetic acid enhanced MRI (Gd-DTPA MRI)' the enhancing areas closely correlated with the areas of tumor stain in IA DSA In conclusion. IA DSA is a good imaging tool and Gd-DTPA MRI is expected to become a more useful modality in the e、raluation of tumor r espo nse to chemotherapy in osteogenic sarcoma Index Words: Extremities. neoplasms 45.3221 Bone neoplasms. MR studies 40.1214 Bone neoplasms. angiography 40.124 Bone neoplasms. therapy 40.1299 서 론 구제술에 의한 치료법이 널리 사용되고 있다 (7). 저자들은 수술 전에 동맥내 항암치료에 따른 종양괴사 의 정도를 방사선학적 검사 소견의 변화가 반영할 수 있 는가를 판정하기 위하여 동맥내 항암치료와 병행하여 동 맥내 디지 탈감산혈관조영술 (intraarterial digital su btraction angiography, IA DSA) 과 자기 공명 영 상술 ( magneti c reso nance image , MRI) 을 시행하여 그 소견의 변화를 분석하여 병리조직에서의 종양괴사의 정도와 비교하여