t(7;11)(p15;p15) NUP98/HOXA13

Aurelia M Meloni-Ehrig
2018 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Several t(7;11)(p15;p15) have been reported in myeloid neoplasms. The most common is the one leading to a fusion between the NUP98 (11p15) and the HOXA9 (7p15). A more rare t(7;11) is the one that leads to a fusion between the NUP98 and the HOXA13 gene on 7p15. This particular t(7;11) is associated primarily with acute myeloid leukemia (AML), primarily FAB M2 and M4. However, it has been reported also in one case of chronic myelogenous leukemia (CML) in blast crisis. The NUP98/HOXA13 fusion
more » ... ein is thought to promote leukemogenesis through inhibition of HOXA13-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport. . The protein encoded by the
doi:10.4267/2042/68741 fatcat:l7cibeknxjgjnpbic3xfpltbhu