Pestalactams A–C: novel caprolactams from the endophytic fungus Pestalotiopsis sp

Rohan A. Davis, Anthony R. Carroll, Katherine T. Andrews, Glen M. Boyle, Truc Linh Tran, Peter C. Healy, John A. Kalaitzis, Roger G. Shivas
2010 Organic and biomolecular chemistry  
Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different
more » ... two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.
doi:10.1039/b924169h pmid:20449480 fatcat:yetdfkrdtjdmlefz4nuwnglo6a