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Progress and challenges in the computational prediction of gene function using networks: 2012-2013 update
2013
F1000Research
In an opinion published in 2012, we reviewed and discussed our studies of how gene network-based guilt-by-association (GBA) is impacted by confounds related to gene multifunctionality. We found such confounds account for a significant part of the GBA signal, and as a result meaningfully evaluating and applying computationally-guided GBA is more challenging than generally appreciated. We proposed that effort currently spent on incrementally improving algorithms would be better spent in
doi:10.12688/f1000research.2-230.v1
pmid:24715959
pmcid:PMC3962002
fatcat:zww622btrvcevdzpq6acwrz5sa