Changing trends in the aetiology and management of male urethral stricture disease: A survey from 13 centres in China

Lu-Jie Song, Yue-Min Xu, Kun-Jie Wang, Jian Lin, Guang Sun, Zhong-Jin Yue, Hai Jiang, Yu-Xi Shan, Shao-Xing Zhu, Yu-Jie Wang, Zhi-ming Liu, Zhen-Hua Li (+3 others)
2015 Urological Science  
Purpose: To compare the efficacy of prophylactic antibiotics in reduction of post-operative infections in patients undergoing ureterorenoscopy (URS) as the intervention. Materials and Methods: The study is a open-labeled, prospective, randomized controlled trial. Between 2012 to 2015, 45 patients with preoperative sterile urine undergoing URS were randomly and eqully allocated by the randomization to three groups, and each group received prophylactic antibiotics with single-dose intravenous
more » ... ose intravenous cefazolin (1gm), oral cefuroxime (500mg) or placebo (control group), respectively. The Urine analysis and urine cultures were obtained around postoperative day 5 to 7. We defined pyuria as WBCS 10/HPF at urine sediment study, and significant bacteriuria was defined as S105 CFU pathogens/ml in the urine. Febrile urinary tract infection (fUTI) was defined as body temperature more than 38 Celsius degree with pyuria or significant bacteriuria within 7 days post-operatively. Results: Total 45 patients were recruited for the analysis. The postoperative pyuria were significantly lower in patients with prophylaxis than the placebo group (42.2% vs. 70.0%, p ¼ 0.04). Patients receiving prophylactic antibiotics with cefazolin and oral cefuroxime were subjected to significantly lower risks of pyuria compared with the control group (36.0% and 48.5% vs. 70.%, p < 0.05). There are the trends that the rates of bacteriuria and fUTI were be lower in patients underwent prophylaxis, though they were not statistically significant (3.5% vs 9.8%, p ¼ 0.1, 1.1% vs. 4.9%, p ¼ 0.08). There was no significant difference in rates of bacteriuria and fUTI between the three groups. Conclusions: Antibiotic prophylaxis significantly reduces the incidence of pyuria following URSL and tends to decreased the risk of bacteriuria and UTI. Abstracts / Urological Science 26 (2015) S26eS35 S32
doi:10.1016/j.urols.2015.06.024 fatcat:ghr6lohye5chnnqicnat42sydu