Systematic analysis of carotenogenesis in microalgae for model-based process design
The topic of this thesis belongs to the broad field of algal biotechnology. This thesis presents a holistic approach for the analysis, optimization and design of microalgal bioprocesses from the systems engineering point of view. This is motivated by the fact that engineering of biosystems is accompanied by many hurdles in the biological and experimental field due to limited mechanistic knowledge and their inherent variability and complexity. The experimental foundations of this work were
... his work were accelerated by recent advances in systems biology that led to new accurate and quantitative experimental techniques for the characterization of biosystems on the cellular level. A synergistic approach facilitating the combination of experimental and mathematical methods will provide a systems-level understanding of the microalgal metabolism under fluctuating environmental conditions and thereby drive the development of sustainable and economically-feasible phototrophic processes. First and foremost, I would like to express my gratitude to Prof. Dr.-Ing. Kai Sundmacher for giving me the opportunity to write my thesis in his research group. I am very grateful for his guidance, the continuous support and trust as well as the scientific freedom in my project. My special thanks goes to Dr. Liisa Rihko-Struckmann for all the time spent on the supervision of my thesis and for her readiness for scientific discussion.