Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016

Imen Bouzouita, Andrea Maurizio Cabibbe, Alberto Trovato, Henda Draoui, Asma Ghariani, Basma Midouni, Leila Essalah, Emna Mehiri, Daniela Maria Cirillo, Leila Slim Saidi
2019 Emerging Infectious Diseases  
To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012-2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.
doi:10.3201/eid2503.181370 pmid:30789128 pmcid:PMC6390739 fatcat:4w5bcitrgbd4bfsiywaxb3tgbq