CASE REPORT Diffuse leptomeningeal metastasis from signet-ring cell adenocarcinoma of the sigmoid

Nafiseh Mohebi, Mehdi Moghaddasi, Hoda Karimian
2014 Journal of Case Reports in Practice   unpublished
Colorectal cancer may uncommonly metastasizes to central nervous system, including brain and/or meninges. This often occurs late in the course of the disease and is accompanied with other extracranial metastases, leading to poor prognosis. Rarely, it is the first manifestation of the malignancy. We herein describe a 50-year-old man with sigmoid adenocarcinoma and secondary meningeal involvement, which to the best of our knowledge, is a rare metastasis to the central nervous system. Since a wide
more » ... variety of signs and symptoms are associated with menin-geal carcinomatosis, any neurologic complaint or abnormal physical finding in a patient with a known malignancy should be considered and evaluated seriously. Although we cannot do much to save the patient, in this stage. IntroDuctIon 1 Colorectal cancer (CRC) is, according to the latest announcement of the American Cancer Society, the third most prevalent cancer and the third most common one leading to death among American men and women. It most commonly metastasizes to regional lymph nodes and liver; brain is among the rare sites for CRC metastasis 1 , and there are some reports of leptomeningeal involvement. 2-4 As a matter of fact, meningeal carcinomatosis (MC) is most commonly a result of breast cancer, lung cancer, and melanoma 5 ; it is infrequently associated with CRC. 6 We report a 50-year-old man with leptomeningeal metastasis and cranial nerve palsies from sigmoid adencarcinoma.