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ER membranes exhibit phase behavior at sites of organelle contact
Proceedings of the National Academy of Sciences of the United States of America
The endoplasmic reticulum (ER) is the site of synthesis of secretory and membrane proteins and contacts every organelle of the cell, exchanging lipids and metabolites in a highly regulated manner. How the ER spatially segregates its numerous and diverse functions, including positioning nanoscopic contact sites with other organelles, is unclear. We demonstrate that hypotonic swelling of cells converts the ER and other membrane-bound organelles into micrometer-scale large intracellular vesiclesdoi:10.1073/pnas.1910854117 pmid:32179693 fatcat:ybd4dm53ofdm5pjf3oirucinoa