Assessment of the luteolytic potency of various prostaglandins in the pseudopregnant rabbit

S. J. Kehl, J. C. Carlson
1981 Reproduction  
The ability of systemic infusion of arachidonic acid and various prostaglandin (PG) compounds to induce luteolysis was examined in the Day 9 pseudopregnant rabbit. Administration of PGF-2\g=a\(25 \g=m\g/h for 6 h) elicited a decline in plasma progesterone from mean \ m=+-\s.e.m. pretreatment levels of 8\m=.\83\ m=+-\ 0\m=.\54to 0\m=.\54\ m=+-\0\m=.\05 ng/ml on the following day (P < 0\m=.\01). A shorter infusion (25 \g=m\g/h for 3 h) or a lower hourly dose rate (12\m=.\5\g=m\g/h for 6 h) of
more » ... g/h for 6 h) of PGF-2\g=a\was ineffectual, suggesting that a dose/duration regimen exists for PGF-2\g=a\-mediated luteolysis. PGE-2 (25 \g=m\g/h for 6 h) or sodium arachidonate (667 \g=m\g/h for 6 h) did not significantly affect luteal function. Of the PGF-2\g=a\metabolites examined, 13,14\x=req-\ dihydro-PGF-2\g=a\ was the most effective: it was approximately 4-fold more potent as a luteolysin than PGF-2\g=a\since functional regression occurred with infusion of 6\m=.\25 \g=m\g/h for 6 h. These data illustrate that systemic infusion of PGF-2\g=a\is capable of inducing luteolysis in the rabbit. The metabolite 13,14-dihydro-PGF-2\g=a\may also be involved luteolytically in this species.
doi:10.1530/jrf.0.0620117 pmid:7230119 fatcat:cwkr2lqiwbhf3caqzmntp4oo54