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MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway
2012
Journal of Biological Chemistry
MicroRNAs (miRNAs) are post-transcriptional regulators involved in the regulation of gene expression. Results: miR-449 and miR-34b/c function redundantly in male germ cells. Conclusion: CREM-SOX5-mediated miR-449 expression regulates male germ cell development by targeting the E2F-pRb pathway. Significance: Upstream regulators of miR-449 expression and a redundant role between miR-449 and miR-34b/c in the control of male germ cell development were revealed.
doi:10.1074/jbc.m111.328054
pmid:22570483
pmcid:PMC3381132
fatcat:gtkbkugab5gw3nas626u3e5x6y