MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway

Jianqiang Bao, Ding Li, Li Wang, Jingwen Wu, Yanqin Hu, Zhugang Wang, Yan Chen, Xinkai Cao, Cizhong Jiang, Wei Yan, Chen Xu
2012 Journal of Biological Chemistry  
MicroRNAs (miRNAs) are post-transcriptional regulators involved in the regulation of gene expression. Results: miR-449 and miR-34b/c function redundantly in male germ cells. Conclusion: CREM-SOX5-mediated miR-449 expression regulates male germ cell development by targeting the E2F-pRb pathway. Significance: Upstream regulators of miR-449 expression and a redundant role between miR-449 and miR-34b/c in the control of male germ cell development were revealed.
doi:10.1074/jbc.m111.328054 pmid:22570483 pmcid:PMC3381132 fatcat:gtkbkugab5gw3nas626u3e5x6y