Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening for more than 20 years. In the absence of aneuploidy or neural tube defect, these serum markers have also been associated with several placenta-mediated adverse pregnancy outcomes, including preeclampsia, intrauterine growth restriction, and stillbirth. Objective: To assess the effect of maternal alpha fetoprotein and B-HCG in umbilical artery Doppler change in 2 nd trimester. Patients and Method: An

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... nal prospective cohort study, conducted at Al-Elwiya maternity teaching hospital Obstetrics department, from the first of February 2019 to the end of Jan. 2020. Results: The current study was included 50 patients within the mean age (25.7±6.2) years old and the main age group was between 21-30 years (62.0%), normal pregnancy outcome in (88.0%), while preeclampsia found in 4 (8.0%) patients and IUGR in 2 (4,0%). Significant association were found between elevated level of serum HCG and Alpha feto protein with adverse pregnancy outcome (P=0.005). Conclusion: Alpha feto protein and HCG were not significantly related to Doppler change in the current study.