Introduction & Objective: The lymphomas are a group of malignant solid tumors that involving cells of the lymphoreticular or immune system. While primary symptoms of lymphoma could involve head and neck region thus have significant value for dentists. The aim of this study was evaluation of the frequency and epidemiologic data of Lymphoma in Hamadan. Materials & Methods: In this retrospective study, all documented files of malignancies in four teaching hospitals of Hamadan (Mobasher, Sina,

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... an, Imam Khomeini) during 1993-2003 were evaluated. Results: Through 350000 hospital files and 3500 cases of malignancies, 404 cases were Lymphomas. (11/5%) [285 Non-Hodgkin Lymphoma (NHL), 111 Hodgkin diseases (HD), 8 Burkitt Lymphoma (BL)]. Males had a higher incidence of types of Lymphoma (male – to female ratio was 1.6:1). The most common presentation of head and neck in all groups of the Lymphomas was cervical lymphadenopathy and the most common nodes were submandibular and superior cervical nodules. Conclusion: In this study the frequency of NHL was higher than HD and BL respectively that perhaps indicates affected to Lymphoma in all age groups. In this study, NHL was more common in patients older than age 40 years and BL most often in patients younger than 11 years of age.