Inhibition of Cholinesterase by Dialkylcarbamates

Šárka Štĕpánková, Karel Komers, Alena Komersová, Markéta Masopustová, Alexander Čegan
2007 Zeitschrift für Naturforschung C - A Journal of Biosciences  
The pI50 index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N′,N′-dialkylcarbamates were determined. Index pI50 (pI50 = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in a system n-octanol/water (Kow). Obtained results were compared with pI50 and Kow of Exelon®, the
more » ... mmercially used drug against the Alzheimer's disease.
doi:10.1515/znc-2007-3-423 fatcat:5litxlz7avadjpsfvodtz77q74