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Inhibition of Cholinesterase by Dialkylcarbamates
2007
Zeitschrift für Naturforschung C - A Journal of Biosciences
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The pI50 index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N′,N′-dialkylcarbamates were determined. Index pI50 (pI50 = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in a system n-octanol/water (Kow). Obtained results were compared with pI50 and Kow of Exelon®, the
doi:10.1515/znc-2007-3-423
fatcat:5litxlz7avadjpsfvodtz77q74