In Guayaquil there is dengue and it has an exposed population in an endemic – epidemic way, but there is little research on the historical trend of the factors that influence the behavior of dengue. The objective of this work is to relate environmental factors and climate change in the behavior of Dengue in Guayaquil city during the period 2010-2014. A Non - experimental research of a longitudinal type of trend was applied, analyzing the behavior of dengue with rainfall, temperature, humidity

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... d winds per epidemiological weeks. The results with more cases were in the years 2010, 2012 and 2014; Showing variability in their behavior. The environmental variables showed that the rainfall has little relation in the presence of cases, humidity findings above 70% with high temperatures and few winds cause conditions to increase the transmission of the disease, but there are epidemiological periods where the transmission decreases and may be related to low average temperatures, relative humidity and presence of winds. At the same time, it is relevant to observe the relationship between the increase in sea surface temperature and the increase in Dengue cases as observed in the years of more cases.