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A Phosphodiesterase-5 Inhibitor Vardenafil Enhances Angiogenesis Through a Protein Kinase G-Dependent Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway
2010
Arteriosclerosis, Thrombosis and Vascular Biology
Objective-We examined whether phosphodiesterase-5 (PDE5) inhibition can promote ischemia-induced angiogenesis. Methods and Results-Unilateral hindlimb ischemia was generated by resecting right femoral artery in wild-type C3H/He mice, treated with either vehicle or a PDE5 inhibitor vardenafil (10 mg/kg per day). Four weeks after surgery, vardenafil significantly enhanced blood flow recovery and augmented capillary collateral formation in ischemic muscle (blood flow ratios of ischemic/nonischemic
doi:10.1161/atvbaha.109.201327
pmid:20413734
fatcat:2m46snaddzf3dgloci33ftrsse