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Validation of HPLC method for determination of atorvastatin in tablets and for monitoring stability in solid phase
Acta Poloniae Pharmaceutica - Drug Research
A rapid high performance liquid chromatographic method was developed and validated for determination of atorvastatin in pharmaceutical dosage forms, and for evaluation of its stability in the solid phase. Separation of atorvastatin was successfully achieved on a C-18 column utilizing water--acetonitrile at the volumetric ratio of 48:52, adjusted to pH 2.0 with 80% ortho-phosphoric acid. The detection wavelength was 245 nm. The method was validated and the response was found to be linear in thepmid:17438862 fatcat:uocrc7wz3vfafo3dbjfbpolkfq