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Pyran (copolymer of divinyl ether and maleic anhydride) and tilorone [2,7-bis(2-diethylaminoethoxy) fluoren-9-one dihydrochloride] are host resistance-inducing agents that possess antitumor activity. The possible relationship of direct cytotoxicity to antitumor activity against the Lewis lung carcinoma and B-16 melanoma tumors was examined. Tilorone and tilorone congeners exhibited significant cyto toxicity in vitro for both tumor cells and normal cells. In general the 50% cytotoxic dosespmid:4812258 fatcat:o7linhsi4nfczca3ctiazifg7i