A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpatients in a tertiary teaching hospital in China [post]

Zhangrui Zeng, Yinhuan Ding, Gang Tian, Kui Yang, Jian Deng, Guangrong Li, Jinbo Liu
2020 unpublished
Background There are no current national estimates of the candidaemia burden in China, and epidemiological candidaemia data from the underdeveloped region of China are lacking. Methods A 7-year retrospective study was carried out to analyse the prevalence, species distribution, antifungal susceptibility, risk factors and inpatient mortality of candidaemia among paediatric and adult paitents in a regional tertiary teaching hospital in China. Results During the seven-year study period, a total of
more » ... period, a total of 201 inpatients with candidaemia were identified. The median age of the patients was 65 years (range, 1 day to 92 years), and 114 of the patients (56.7%) were male; the mean annual incidence was 0.26 cases per 1,000 admissions (0.42 cases per 1,000 paediatric vs 0.24 cases per 1,000 adult admissions, P<0.05). Candida albicans was the most common fungal species (81/201, 40.3%) in all patients, Candida glabrata was the most common fungal species (18/35, 51.4%) in paediatric patients. Most isolates were susceptible to flucytosine (99.0%) and amphotericin B (99.0%), and the activity of antifungal agents against Candida species was no significant difference in satisfaction between paediatric and adult patients(P>0.05). The all-cause mortality rate was 20.4% (paediatric patients: 11.4% vs adult patients:22.3%, P>0.05). The univariate predictors of poor outcomes in paediatric patients were less than that in adult patients (4 vs 11 predictors). Respiratory dysfunction and septic shock were independent predictors of 30-day mortality in all patients. Conclusions The epidemiological data of candidaemia in paediatric and adult patients are only different in the distribution of Candida species and the mean annual incidence of candidaemia. Flucytosine and amphotericin B could be used as the first-choice agent when there is no the result of antifungal susceptibility tests.
doi:10.21203/rs.3.rs-24682/v1 fatcat:5qhoqc5xx5advln446m2cz5fdy