Epsin potentiates Notch pathway activity in Drosophila and C. elegans

X. Tian
2004 Development  
We extended the link between the Notch pathway and epsin function to C. elegans, where the C. elegans lqf ortholog acts in the signaling cell to promote the glp-1/Notch pathway activity during germline development. Our results suggest that epsins play a specific, evolutionarily conserved role to promote Notch signaling during animal development and support the idea that they do so by targeting ligands of the Notch pathway for endocytosis.
doi:10.1242/dev.01459 pmid:15539484 fatcat:vtqc73ioozattjdunu3balvncm