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Eficácia terapêutica e segurança de metotrexato + leflunomida em pacientes colombianos com artrite reumatoide ativa refratária ao tratamento convencional
Revista Brasileira de Reumatologia
The combination of methotrexate (MTX) + lefl unomide (LFN) has been shown to be effective in the treatment of RA. Its safety has been questioned. Objective: To evaluate the effectiveness and safety of the combination of MTX + LFN in patients with active RA. Methods: This was a 24-week multicenter study, which included 88 patients with active disease despite consistent treatment with methotrexate and prednisolone. Results: We included 78 women (88%) and 10 men. The age was 51.3 ± 12.4 years, anddoi:10.1590/s0482-50042012000600003 fatcat:6z5kfblubjfw5dgw7nxidwfjwe