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Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB 2 R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance. These effects are specific to CB 2 R since no changes were observed in mice where the gene coding for this receptor was altered (cnr2 2/2 ). The CB 2 R induced morphological changesdoi:10.1371/journal.pone.0070849 pmid:23951024 pmcid:PMC3739758 fatcat:koonrkwy4vgdxdzeu57yo36soa