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Antimuscarinic actions of antihistamines on the heart
2006
Journal of Biomedical Science
Antimuscarinic side-effects, which include dry mouth, tachycardia, thickening of mucus possibly sedation, of the antihistamines limited the usefulness of these drugs. The advent of newer agents has reduced the sedative effect of the antihistamine. The data presented here show that one of the newest antihistamines, desloratadine, and a first generation drug, diphenhydramine, are both competitive inhibitors of muscarinic receptor mediated slowing of the heart as measured using a Langendorff
doi:10.1007/s11373-005-9053-7
pmid:16453179
fatcat:sr5iyvc2grgbvpraiapfevkhxy