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Progranulin and TMEM106B: when two become wan
2020
EMBO Reports
Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condition. TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. While the specific relationship between progranulin and TMEM106B is unclear, it is well established
doi:10.15252/embr.202051668
pmid:32985120
pmcid:PMC7534635
fatcat:hublgufnlre3zf2stkz6yyhye4