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Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism
2018
Science Advances
The study of metabolism has provided remarkable information about the biological basis and therapeutic weaknesses of cancer cells. Classic biochemistry established the importance of metabolic alterations in tumor biology and revealed the importance of various metabolite families to the tumorigenic process. We have evidence of the central role of polyamines, small polycatonic metabolites, in cell proliferation and cancer growth from these studies. However, how cancer cells activate this
doi:10.1126/sciadv.aar2606
pmid:29376126
pmcid:PMC5783676
fatcat:wpubsrgihbhedezxnhqasxg4re