The neutrophil-lymphocyte ratio is positively correlated with aggression in schizophrenia [post]

Zhu Tong, Jing Zhu, Jiajia Wang, Yujing Yang, Wei Hu
2022 unpublished
To find biomarkers to assess the risk of aggression, we looked at the association between aggression and levels of body inflammation in patients with schizophrenia. The Modified Overt Aggression Scale (MOAS) score was used to divide the aggressive (n=72) and non-aggressive (n=141) groups. The BPRS (Brief Psychiatric Rating Scale) is a tool for determining the severity of a patient's condition. After measuring the number of inflammatory cells in the peripheral blood, the platelet-lymphocyte
more » ... (PLR), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were estimated. We investigated the relationship between aggressive behavior, bodily inflammation, and BPRS. Before therapy, the aggressive group's BPRS score, white blood cell(WBC) count, Neutrophils count, Monocyte count, NLR, and MLR were considerably more significant than the non-aggressive group's. After therapy, statistically significant variations in total BPRS score and Neutrophils count between the two groups. According to correlation analysis before and after treatment, aggressive behavior was positively connected with Neutrophils count, NLR, and BPRS score. The presence of aggressive behavior in schizophrenic patients indicates the severity of the disorder to some degree. NLR can be used as an objective biomarker to assess the risk of aggression in schizophrenic patients quickly.
doi:10.21203/ fatcat:oenlo6uzpjafrjhzxcgtirhppa