Peer Review #1 of "Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish (v0.2)" [peer_review]

A Laird
2017 unpublished
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus-pituitary-adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish . We demonstrate that fluoxetine blunts the response to physical stress, but not
more » ... to chemical stress. PeerJ reviewing PDF | Manuscript to be reviewed 24 Abstract 25 Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin 26 concentration in the central nervous system and modulates various systems, including the control 27 of sympathetic outflow and the hypothalamus-pituitary-adrenal. However, it is not yet 28 established whether fluoxetine can modulate the responses to stressor stimuli (physical or 29 chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the 30 response to physical stress, but not to chemical stress. 31 32 33 34 35 36 37 38 39 40 PeerJ reviewing PDF |
doi:10.7287/peerj.3330v0.2/reviews/1 fatcat:6r3yv2vx65aifj2da3akengxau