June 3, 1871.] THE BRITISH MEDICAL .OURNAL. inflamed, and that the vaccination did not seem to take the usual effect. Muchinflammation, swelling, and irritation, occurred, anda rashappeared around and upon the part, which festered and became sore and scabby. The pityriasis was mixed up with the herpes, and soon extended to the neck and chest, and thence to the abdomen and thighs, and even to the sole of the left foot, where there had long existed a small patch of psoriasis. The irritation

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... ing these eruptions had, doubtless, caused the patient to carry them from place to place with his fingers, and thus produce the extension of the complaint. The patient was in good average health for a man of his age; the constant irritation constituting the chief feature of his ailment. Parasiticides externally and magnesian aperients, with small doses of colchicum to restrain the irritation, and sulphur vapour baths, were prescribed; and I have little doubt that, at our next interview, the report will be favourable. The last two cases which I have to report, though fortunately the most rare, are also the most important, as they are undoubted instances of vaccino-syphilis, in all probability communicated from the same vaccinifer. These two patients were sent, or rather brought, to me at an interval of eighteen days by two surgeons in a partnership firm, enjoying an extensive local and county practice. In these cases, as in the former, I am precluded from mentioning names, as explained by the following note, which 1 take the liberty of transcribing in consequence of the importance of the subject. "May 25th, I87I.