Results: Systemic arterial blood pressure significantly decreased after exsanguination and elevated after infusion. In the HbV, lowP 50 -HbV as well as rat-RBC groups, all the rats were liberated from mechanical ventilation and the blood pressure was stabilized, although all the rats of the saline group and 30% of the albumin group died within 1 hour after extubation. Partial pressure of oxygen in arterial blood (PaO 2 ) for 1 hour after liberation from mechanical ventilation in the rat-RBC,

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... and lowP 50 -HbV groups were 59.4612.5, 58.3610.1, and 70.5614.5 mmHg, respectively. The PaO 2 of the lowP 50 -HbV group was significantly higher than those of the ratRBC and HbV groups (P¼0.05 for both). Elevation of serum lactate due to hypoxic damage was minimized by HbV or lowP 50 -HbV as well as rat-RBC. Conclusions: The ability of HbV as oxygen carrier was comparable with rat-RBC even under impaired lung function after pneumonectomy in evaluation of haemodynamic stability and arterial blood oxygenation. HbV with high oxygen affinity may have more advantageous effect on oxygenation in pulmonary resection. Disclosure: No significant relationships.