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Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death
2006
Biological chemistry
One of the control mechanisms of cathepsin B biosynthesis and trafficking operates through alternative splicing of pre-mRNA. An mRNA lacking exon 2 is more efficiently translated than that containing all exons, and may be responsible for elevated biosynthesis and enzyme routing to the extracellular space, with critical consequences for connective tissue integrity in pathologies such as cancer and arthritis. mRNA missing exons 2 and 3 encodes a truncated procathepsin B form that is targeted to
doi:10.1515/bc.2006.125
pmid:16895470
fatcat:cpecfembyjglnb3gqiqria3lca