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Int J Gastroenterol Hepatol Transpl Nutr
In the pathophysiology of non-insulin dependent diabetes, characterized by hyperglycemia, at least three factors seem to be involved: a defect in insulin secretion, increased hepatic glucose production and insulin target. Over the past decade, significant advances in knowledge about the cellular mechanisms of action of insulin were performed. This has led to a better understanding of the mechanisms that could explain the insulin resistance in the type 2 diabetes, regardless of their primary orfatcat:zmf3aeo22vdzbc6kkuah4cpsme