Magnesium deficiency: carbohydrate and lipid metabolism disorders and risk of type 2 diabetes

Ghouini Ahmed, Djoghlaf Djamel, El Harb
2016 Int J Gastroenterol Hepatol Transpl Nutr   unpublished
In the pathophysiology of non-insulin dependent diabetes, characterized by hyperglycemia, at least three factors seem to be involved: a defect in insulin secretion, increased hepatic glucose production and insulin target. Over the past decade, significant advances in knowledge about the cellular mechanisms of action of insulin were performed. This has led to a better understanding of the mechanisms that could explain the insulin resistance in the type 2 diabetes, regardless of their primary or
more » ... econdary origin. The deficit of magnesium is frequently associated with diabetes mellitus. This depletion ubiquitous cation in the body, alters glucose metabolism and insulin sensitivity and, is also implicated in the occurrence of complications and the risk of diabetes occurred among subjects predisposed who should receive a follow-up search of a magnesium deficiency, expression of a lack of intake and / or increased urinary loss. In our study, we found a correlation between magnesium deficiency and metabolic disorders affecting carbohydrate and lipid metabolism, labeled with revealing glycemic levels, insulin resistance, and lipid profile. The cause of magnesium deficiency in diabetic patients is not fully known. As the beneficial effects of magnesium supplementation, the long-term studies are needed before recommending routine supplementation in type 2 diabetes and subjects at risk with subclinical magnesium deficiency.