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Interphase-ArrestedDrosophilaEmbryos Initiate Mid-Blastula Transition At A Low Nuclear-Cytoplasmic Ratio
[article]
2017
bioRxiv
pre-print
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. At the 14th cell cycle inDrosophilaembryos, the cell cycle slows, transcription increases, and morphogenesis begins at the Mid-Blastula Transition (MBT). To explore the role of N/C in MBT timing, we blocked N/C-increase by downregulating cyclin/Cdk1 to arrest early cell cycles. Embryos arrested in cell
doi:10.1101/143719
fatcat:2nrh7bohm5el3btjl5d563uyue