Claudin is an Immunohistochemical Changes Associated with Experimental Infection of White Mice with 0111 – of non – 0157 Shiga Toxin Producing Escherichia Coli

2020 Indian Journal of Forensic Medicine & Toxicology  
Immunohistochemical stain for the tissue sections prepared from experimental infection of mice with 0111of non 0157 of shiga toxin producing Escherichia coli .The immunohistochemical changes revealed that the shiga toxin produced by 0111 -STEC effect on epithelial tight Junction ,The IHC stain was directed to detect the claudin ( the structural protein of tight Junction ) revealed absence of this protein in the paracellular sites with discohesion of the epithelial cells in the intestine and
more » ... thelial cells in the brain blood vessels which was responsible for induction of diarrhea and nervous signs
doi:10.37506/ijfmt.v14i4.11834 fatcat:nzqaohravff7dbxizz5nyxpmyq