An Exploratory Cohort Study of the Association Between the Level of Testosterone and Suicidal Ideation in the Hospitalized Adolescent Female With Depression in China [post]

Yan Liu, Shaohua Wang, Chuang Xue, Xiwen Hu, Guoling Zhou, Yuanyue Zhou, Dan Fang, Kaijing Ding, Wencong Chen
2021 unpublished
BackgroundTo date, around 4 per 100, 000 adolescent committed suicide within the 29 OECD countries. The suicidal behavior is related to psychological factors, genetics, neurobiology, and other biomarkers. We aimed to investigate the risk factors for the suicidal ideation, especially the association between suicide ideation and different levels of testosterone in the adolescent female with depression. The goal of this study is to aid the development of strategies to intervene the suicidal
more » ... r for the depressed female adolescent. MethodIn this single center, prospective cohort study, we enrolled adolescent female with depression. We collected baseline demographic data, age adjusted level of testosterone, Symptom Self-rating Scale, and information about the suicidal ideation, non-suicidal self-injury (NSSI), and suicide attempt. We used multivariate logistic regression to determine the risk factors for the suicidal ideation. ResultsTotal 113 hospitalized adolescent female enrolled with a mean age of 13.5 (1.20). Among these patients, there were 86 (76.1%) subjects suffered from the suicidal ideation, while 59 (52.2%) of them had NSSI and 23 (20.4%) had suicide attempt behavior. In the final model, higher level of testosterone (p = 0.04) and higher age (p = 0.02) were associated with the higher odds of having suicidal ideation.ConclusionIn this exploratory cohort study, suicidal ideation was prevalent. It is important to assess the level of testosterone in the adolescent female with depression. This study is consistent with the other studies. It shows the age is a potential predictor for the suicidal ideation in the hospitalized adolescent female with depression.
doi:10.21203/rs.3.rs-535908/v1 fatcat:xgtncqugiza67cnwlvuieduapa