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Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity
1981
Journal of Virology
The nucleotide sequence of the gene coding for the large subunit of influenza virus hemagglutinin (HA1) was determined for strains A/NT/60/68, A/Eng/878/ 69, and A/Qu/7/70, three early isolates of the Hong Kong subtype. Sequences were obtained by the dideoxy chain termination method, using reverse transcriptase to synthesize partial DNA copies of the RNA gene. HAl amino acid sequences predicted from the gene sequences were compared with published data for strains A/Aichi/2/68 and A/Vic/3/75.
doi:10.1128/jvi.37.3.845-853.1981
fatcat:hi2l5zss2fbotalfuzjkhqpxau