Bcl-2 family proteins as ion-channels

Sharon L Schendel, Mauricio Montal, John C Reed
1998 Cell Death and Differentiation  
The Bcl-2 protein family function(s) as important regulators of cellular decisions to heed or ignore death signals. The threedimensional structure of the Bcl-2 homolog, Bcl-X L , bears a strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the Bcl-2 family proteins may also possess channel-forming capability. This review summarizes the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-X L and Bax and offers some speculation as to the
more » ... logical role that these channels may play in the cell death pathway.
doi:10.1038/sj.cdd.4400365 pmid:10200486 fatcat:gpv6vs5ix5ai7dstic5p2mgzc4