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Bcl-2 family proteins as ion-channels
1998
Cell Death and Differentiation
Preserved Fulltext
The Bcl-2 protein family function(s) as important regulators of cellular decisions to heed or ignore death signals. The threedimensional structure of the Bcl-2 homolog, Bcl-X L , bears a strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the Bcl-2 family proteins may also possess channel-forming capability. This review summarizes the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-X L and Bax and offers some speculation as to the
doi:10.1038/sj.cdd.4400365
pmid:10200486
fatcat:gpv6vs5ix5ai7dstic5p2mgzc4