Spongian Diterpenes from the Sponge Hyattella aff. intestinalis

Peni Ahmadi, Takahiro Haruyama, Nobuyuki Kobayashi, Nicole Joy de Voogd, Junichi Tanaka
2017 Chemical and pharmaceutical bulletin  
Extracts of the sponge Hyattella aff. intestinalis showed moderate inhibition against adenovirus. Chromatographic separation of the extracts followed by analysis of spectroscopic data allowed us to elucidate the structures of three new metabolites as 2α-hydroxyspongia-13(16),14-diene-3-one (4), 3β-hydroxyspongia-13(16), 14-diene-2-one (7), and 2α,3α-diacetoxy-17,19-dihydroxyspongia-13(16),14-diene (8) and to identify six known ones 1-3, 5, 6 and 9. Among the molecules, compounds 1 and 3 showed antiviral activity at IC 50 17.0 and 52.0 µM.
doi:10.1248/cpb.c17-00297 pmid:28652548 fatcat:jweqtjfmrngpphkpsjx65yd2ze