We report here, and rationalize, a synergistic effect between a non-noble metal oxide catalyst (CuO) and high frequency ultrasound (HFUS) on glucose oxidation. While CuO and HFUS are able to independently oxidize glucose to gluconic acid, the combination of CuO with HFUS led to a dramatic change of the reaction selectivity, with glucuronic acid being formed as the major product. By means of DFT calculations, we show that, under ultrasonic irradiation of water at 550 kHz, the surface lattice

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... en of a CuO catalyst traps H• radicals stemming from the sonolysis of water, making the ring opening of glucose energetically non-favorable and leaving a high coverage of •OH radical on the CuO surface which selectively oxidize glucose to glucuronic acid. This work also points towards a path to optimize the size of the catalyst particle for an ultrasonic frequency which minimizes the damage to the catalyst, resulting in its successful reuse.