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Mechanisms by which the N-terminal 24 amino acids of the p55 regulatory subunit of phosphatidylinositol 3-kinase affect endotoxin-induced cytokine release in human keratinocytes
Molecular Medicine Reports
To understand the association between the cytokine network and psoriasis, the present study cultured human keratinocytes (HaCaT cells) and investigated the effects of the phosphatidylinositol-3-kinase (PI3K) p55 regulatory subunit (p55PIK), and its N-terminal 24 amino acids (N24) on the regulation of endotoxin (LPS)-induced cytokine secretion. The results of the enzyme-linked immunosorbent assay and reverse transcription quantitative polymerase chain reaction revealed an increased release ofdoi:10.3892/mmr.2015.3184 pmid:25585688 fatcat:5kl2ftwugbgmzd4cbzelvino4m