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Recognize the role of CD146/MCAM in the osteosarcoma progression
Background: Osteosarcoma (OS) is a common malignant bone tumor with poor prognosis. We previously reviewed that CD146 is correlated with multiple cancer progression, while its impact on OS is currently not systematically studied. Methods: we transfected MG63 with lentivirus to express CD146 ectopically, combining with anti-CD146 neutralizing antibody ab75769 to inhibit 143B, to observe the intrinsic relationship between CD146 and OS. In addition, we used Transwell co-culture system anddoi:10.21203/rs.3.rs-328507/v1 fatcat:2tkpry3tg5gldhajwohtfctqoq