Theclinical application value ofFAM19A4/mir124-2 methylation test in hrHPV-positive women

Xiaohua He, Inner Mongolia Medical University
2022 Cancer cell research  
Cervical cancer is one of the most common malignancies in women. The combination of human papillomavirus (HPV) genotyping with thinprep liquid-based cytology test (TCT) of cervical exfoliated cells and HPV vaccine helps greatly for the early diagnosis and prevention of cervical cancer. However, there is still a certain risk of missed diagnosis or over-diagnosis due to the limitations of its methodology. Therefore, women infected with high-risk HPV (hrHPV) need more reliable tests to identify
more » ... ther the lesions will progress to cancer, which can guide early and accurate treatment and prevent over-treatment. Recently, studies have found that FAM19A4/mir124-2 methylation is closely related to cervical cancer, and its methylation degree increases with the severity of cervical lesions, which is expected to become a new biomarker of cervical cancer. Here, we summarized the clinical application value of FAM19A4/mir124-2 methylation test in hrHPV-positive women.
doi:10.54762/ccr2022.836-840 fatcat:sib4tnpcffcsrnyublcb235kfy